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Rimcazole dihydrochloride

CAS No. 75859-03-9

Rimcazole dihydrochloride( —— )

Catalog No. M33914 CAS No. 75859-03-9

Rimcazole dihydrochloride is the hydrochloride salt of Rimcazole, a σ receptor antagonist. Rimcazole dihydrochloride also binds to dopamine transporter proteins and inhibits dopamine uptake.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rimcazole dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Rimcazole dihydrochloride is the hydrochloride salt of Rimcazole, a σ receptor antagonist. Rimcazole dihydrochloride also binds to dopamine transporter proteins and inhibits dopamine uptake.
  • Description
    Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.
  • In Vitro
    Western Blot AnalysisCell Line:HCT-116p53+/+ cells Concentration:50 μM Incubation Time:1, 2, 3, 5, 6, 24 hours Result:Accumulation of HIF-1α protein, maximal at 6?h.No change in p53 protein levels.HIF-1α protein levels returned to normal steady-state levels within 24?h.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    75859-03-9
  • Formula Weight
    357.92
  • Molecular Formula
    C21H28ClN3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (31.70 mM; Ultrasonic (<60°C); )H2O : < 0.1 mg/mL (insoluble)
  • SMILES
    Cl.Cl.C[C@H]1CN(CCCn2c3ccccc3c3ccccc23)C[C@@H](C)N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gilmore DL, et, al. Review of the pharmacological and clinical profile of rimcazole. CNS Drug Rev. Spring 2004;10(1):1-22.?
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